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Image Search Results
Journal: Journal of chemical information and modeling
Article Title: Ligand-Based Discovery of a New Scaffold for Allosteric Modulation of the μ -Opioid Receptor
doi: 10.1021/acs.jcim.5b00388
Figure Lengend Snippet: Allosteric EC50 shifts of endomorphin-1-stimulated β-arrestin recruitment in CHO-μ PathHunter cells in the presence of increasing concentrations of PAM: MS1 (A), MS2 (B), MS3 (C), and BMS-986121 (D). Kb = calculated binding affinity of PAM to free receptor; α = allosteric cooperativity factor.
Article Snippet: Y = bottom + (top − bottom)/(1 + 10 ((logEC 50 − X )×Hill slope) ) (1) The β -arrestin curve shift assays in were analyzed using an
Techniques: Binding Assay